Some ingredients can move through the skin because they are small and can slip between the tiny gaps in the outer layer. The skin blocks large and heavy molecules, but smaller nutrient compounds can pass through more easily when they mix well with surface oils (lipophilic). This lets an Endorfix skin deliver microdoses in slow steps through the day. It keeps the effect steady and avoids stomach breakdown or fast spikes like you would see with energy drinks or coffee.
Requirements for Skin Penetration
These are the three core requirements for an ingredient to pass through skin and reach the bloodstream:
1. Molecular Size (Daltons)
The stratum corneum works as the main skin barrier.
Only small molecules can move through this layer.
The “500 Dalton Rule” is based on dermatology research that shows molecules above 500 Daltons cannot penetrate the skin barrier.
A PubMed-indexed study explains that allergens, topical medicines, and transdermal drugs all fall below this weight, which supports the rule.
(Source: PubMed ID 10839713, “Human skin and the 500 Dalton rule”).
2. Lipophilicity (Oil-Friendly Structure)
Skin is rich in lipids.
Oil-friendly ingredients move through these lipids with more ease.
Many plant extracts contain lipophilic parts that help absorption.
3. Stability on the Skin Surface
The ingredient must not break down fast on the skin surface.
It needs time to diffuse.
A patch keeps the ingredient in place so it can move in small steps.
Ingredients in our Energy Skins
Most ingredients sit below the 500 Dalton range, which means they can pass through the outer skin layer more easily. Other ingredients are there only to help the ingredients permeate the skin. Shop our Energy Skins.
Caffeine
What it does: Boosts energy and mental alertness.
Why it’s included: Improves focus and reduces fatigue.
Why it absorbs: caffeine is a small molecule and mixes well with skin lipids, so it can move through the surface layer.
D Glucuronolactone
Purpose: light energy support and metabolic balance.
Why it absorbs: it is a small and water-soluble compound that travels into surface layers without resistance.
Taurine
What it does: Supports cardiovascular function and muscle performance.
Why it’s included: Enhances endurance and electrolyte balance.
Why it absorbs: taurine is a very small amino-sulfonic acid, which makes it able to diffuse through the outer skin layer.
Guarana Extract
What it does: Provides natural caffeine and enhances alertness.
Why it’s included: Increases energy and mental performance.
Why it absorbs: guarana contains caffeine and other small xanthine molecules, which move well through skin lipids.
Green Tea Extract (EGCG + catechins)
What it does: Provides antioxidants and metabolic boost.
Why it’s included: Helps fight oxidative stress and supports fat metabolism.
Why it absorbs: catechins sit in the low-to-mid molecular range and have lipid-friendly behaviour that helps surface absorption.
L-Theanine
What it does: Promotes relaxation without drowsiness and stress reduction.
Why it’s included: Balances caffeine’s effects and improves focus.
Why it absorbs: theanine is a small amino acid that passes through tight layers with ease.
B-Vitamins (B3, B5, B6, B12)
B3 (Nicotinamide)
- What it does: Helps convert food into usable energy.
- Why it’s included: Supports metabolism and cellular energy production.
B5 (D-Calcium Pantothenate)
- What it does: Assists hormone synthesis and energy release.
- Why it’s included: Aids metabolism and reduces fatigue.
B6 (Pyridoxine Hydrochloride)
- What it does: Facilitates protein metabolism and cognitive function.
- Why it’s included: Helps brain health and neurotransmitter production.
B12 (Cobalamin)
- What it does: Supports red blood cell formation and nervous system.
- Why it’s included: Boosts energy levels and overall vitality.
Ginkgo
What it does: Supports blood circulation and cognitive function.
Why it’s included: Can enhance memory and mental clarity.
Rhodiola
What it does: Helps reduce stress and combat fatigue.
Why it’s included: Improves endurance, mood, and resilience.
Ingredients in Our Appetite Suppressant Patches
Also for our Appetite Patches most ingredients sit below the 500 Dalton range, which means they can pass through the skin barrier when used in a transdermal patch.
Each compound supports appetite control through small molecular size, lipid behaviour, or follicle uptake. Shop our Appetite Skins.
5-HTP
What It Does: Boosts serotonin levels to improve mood and control emotional eating.
Why It’s Included: Helps you stay positive and motivated on your journey.
Why it absorbs: small amino-acid derivative that fits within the skin-permeation range.
Garcinia Cambogia (HCA)
What It Does: Naturally curbs appetite and reduces cravings.
Why It’s Included: Helps you feel satisfied and in control of your hunger.
Alpha-Lipoic Acid (ALA)
What It Does: Supports cellular energy production and metabolic efficiency.
Why It’s Included: Helps your body convert food into usable energy.
Forskolin (Coleus Forskohlii)
What It Does: Promotes fat metabolism and thermogenesis.
Why It’s Included: Encourages your body to use stored fat for energy.
Capsaicin (Capsicum Extract)
What It Does: Increases calorie burn by gently raising your metabolism.
Why It’s Included: Enhances the effectiveness of other ingredients.
Green Tea Extract
What It Does: Supports fat oxidation and boosts energy without overstimulation.
Why It’s Included: Provides a gentle metabolic boost to help you stay energized and focused.
Yerba Mate Extract
What It Does: Provides sustained energy and mental clarity.
Why It’s Included: Keeps you sharp and focused throughout the day.
Fucoxanthin
What It Does: Encourages overall fat loss by supporting metabolic activity.
Why It’s Included: Supports gradual, sustainable weight management.
Bitter Orange (Synephrine)
What It Does: Enhances energy levels and helps suppress appetite.
Why It’s Included: Provides that extra push to keep cravings at bay.
Frequently Asked Questions
Where should I wear an Endorfix patch?
You can place a patch on clean and dry skin.
Most people use the shoulder, collar bone, or wrist because these areas stay still through the day.
A discreet transdermal patch stays in place and uses transdermal technology to release microdoses through your skin.
How long can I wear each patch?
Energy Patch: Most people wear it for 6–8 hours of steady support. The patch size is 3×3 cm.
Appetite Suppressant Patch: Most people wear it for 10–12 hours, but you can remove it anytime. If you want shorter or longer use, just add or remove the patch as you see fit. The patch size is 6×6 cm.
Do Endorfix Appetite Patches replace a diet plan?
No. Appetite skins support your routine with its appetite-suppressing activities, but they do not replace a balanced diet or healthy lifestyle plan.
They give support with cravings and offer a simple way to manage daily battles with hunger so you stay more in control of your eating and stay on track with ease.